ICON-MENU-2023

Personalized Medicine in the Making

Springer
By combining humanistic and scientific lenses, this work builds up a multidimensional way of understanding the limits and potentialities of a personalized approach in medicine and healthcare. Furthermore, as the title suggests, it provides theoretical foundations for implementing personalized medicine.

The chapters that comprise this collection enter into detail regarding what constitutes “personalized medicine.” The features with which it is associated are in constant interaction with new scientific and technological discoveries, changed social problems and needs, and further conceptual investigations. Thus, the concept does not yet have a standard, precise, definition.

In other words, “personalized medicine” is a concept whose meanings, limits, potentialities, and challenges are constantly developing. The papers collected in this volume acknowledge this mutability, while at the same time identifying common themes and ideals as well as challenges.

The book reflects on the relationships that personalized medicine has with complex diseases; with new biotechnologies; and with personalized nutrition. It also considers some of the ethical, political, economic, and social implications of this approach.

The work will be of interest to researchers and practitioners from varied disciplines including philosophy, biomedicine, and the social sciences. It stems from the STI Experts Meeting ‘Personalized Medicine. A Multidisciplinary Approach to Complexity,’ held at the University Campus Bio-Medico of Rome, Italy, in February 2020.

The volume is available for purchase in hardcover and ebook editions on this Springer link. It is the third in the Springer series “Human Perspectives in Health Sciences and Technology,” which publishes volumes that delve into the coevolution between technology, life sciences, and health sciences. Professor Bertolaso serves as series editor.

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Part I: Personalized Medicine: From Biology to Clinics

Why Precision Oncology Is Not Very Precise (and Why This Should Not Surprise Us)
Anya Plutynski

The Complexity of Tumor Heterogeneity: Limitations and Challenges of the Pharmacogenomics in Cancer Treatment
Guglielmo Militello and Marta Bertolaso

Conceptual and Theoretical Specifications for Accuracy in Medicine
Maël Montévil

Personalized Treatments: Where Patient’s History and Biological Background Meet
Mariano Bizzarri, Andrea Pensotti, Alessandra Cucina, Noemi Monti, and Valeria Fedeli

Personalised Prevention: Increasing or Decreasing Over-Medicalisation, Overdiagnosis and Overtreatment?
Julia Tinland

Making Feasible Personalized Nutrition: Between Science and Daily Habits
Laura Dugo, Andrea Pensotti, and Vincenzo Fogliano

Part II: Personalized Technology: From Epistemology to Data Management

Patient-Derived Organoids in Precision Oncology – Towards a Science of and for the Individual?
Sara Green, Mie S. Dam, and Mette N. Svendsen

Pharmacovigilance as Personalized Evidence
Francesco De Pretis, William Peden, Jürgen Landes, and Barbara Osimani

New Solutions to Biomedical Data Sharing: Secure Computation and Synthetic Data
Edwin Morley-Fletcher

Realizing Personalized Medicine Using In Silico Tools: A Community Effort
Liesbet Geris

Part III: Personalized Healthcare: From Ethics to Policies

Exposomics in the Era of Personalized Medicine: A Critical Analysis
Xavier Guchet

Personalized Epigenetics: Prospects and Challenges
Silvia Caianiello

Personalized Medicine and Research Biobanking: From Traditional to New Informed Consent Generating a Need for Participatory Governance
Antonella Ficorilli

Biobank Research and Data Protection Issues Under the GDPR
Maria Rosaria Brizi

Shedding Light on the Application of Pharmacogenomics to the United States Opioid Crises: A Relational Approach
Maria Sophia Aguirre

The Impact of a Fantasy
Roger Strand